Arrangement
It's very important that you can SEE the "Activity" window. It is the only way you can know when certain operations are happening, for example: searching, push/pull meta data, database saving, song zipping / unzipping / playing etc.
I recommend you arrange your windows like below, such that none are overlapped. If you have a 2nd monitor (or a TV) for the "Video" window, then you can just make "Activity" taller. Obviously you can scale this layout to fit your monitor, assuming it is larger.